Thelansis

  Gout is a prevalent cause of chronic inflammatory arthritis, characterized by the deposition of monosodium urate (MSU) monohydrate crystals within tissues. Biochemically, gout is associated with extracellular fluid urate saturation, typically manifesting as hyperuricemia, where plasma or serum urate concentrations exceed 6.8 mg/dL (approximately 400 µmol/L), the threshold of urate solubility. Clinically, gout presents with various manifestations, including acute gout flares (recurrent episodes of inflammatory arthritis), chronic gouty arthropathy, tophaceous deposits due to urate crystal accumulation, uric acid nephrolithiasis, and chronic nephropathy. The etiology of gout is multifactorial, often involving genetic predisposition, medical comorbidities, and dietary factors. In rare instances, a single genetic mutation may lead to gout, typically in conjunction with other medical complications. Regardless of the initial trigger, elevated serum uric acid levels are an expected ou...