Thelansis

  Afibrinogenemia, also called congenital afibrinogenemia, is a rare blood disorder that affects the body's ability to clot. Afibrinogenemia is caused by deficient synthesis of fibrinogen (coagulation factor I) in liver cells resulting from a mutation in fibrinogen genes alpha (FGA), fibrinogen genes beta (FGB), fibrinogen genes gamma (FGG). Its deficiency leads to severe bleeding and hemorrhaging when an injury occurs, and bleeding can occur anywhere in the body, including the skull. In afibrinogenemia, with fibrinogen levels less than 0.1 g/L, bleeding abnormalities range from mild to severe. Symptoms of afibrinogenemia often appear at birth and may include prolonged bleeding from the umbilical cord stump. Early diagnosis is important for proper surveillance and treatment. Milder forms of the condition, called hypofibrinogenemia or dysfibrinogenemia, are associated with some residual fibrinogen function. Women with afibrinogenemia have an increased risk of vaginal bleeding and ...

 Afibrinogenemia, also called congenital afibrinogenemia, is a rare blood disorder that affects the body's ability to clot. Afibrinogenemia is caused by deficient synthesis of fibrinogen (coagulation factor I) in liver cells resulting from a mutation in fibrinogen genes alpha (FGA), fibrinogen genes beta (FGB), fibrinogen genes gamma (FGG). Its deficiency leads to severe bleeding and haemorrhaging when an injury occurs, and bleeding can occur anywhere in the body, including the skull. In afibrinogenemia, with fibrinogen levels less than 0.1 g/L, bleeding abnormalities range from mild to severe. Symptoms of afibrinogenemia often appear at birth and may include prolonged bleeding from the umbilical cord stump. Early diagnosis is important for proper surveillance and treatment. Milder forms of the condition, called hypofibrinogenemia or dysfibrinogenemia, are associated with some residual fibrinogen function. Women with afibrinogenemia have an increased risk of vaginal bleeding and mi...