Thelansis

 ROS1-positive non-small cell lung cancer (NSCLC) is a specific subtype of NSCLC characterized by a genetic alteration involving the ROS1 gene. The ROS1 gene encodes a receptor tyrosine kinase that plays a role in cell growth and proliferation. When the ROS1 gene undergoes a rearrangement or fusion with another gene, it can result in the abnormal activation of the ROS1 protein, leading to uncontrolled cell growth and cancer development. The exact cause of ROS1 rearrangements in NSCLC is not well understood. However, similar to other genetic alterations in cancer, it is believed to occur due to random mutations or exposure to certain environmental factors, such as tobacco smoke or occupational hazards like asbestos. ROS1-positive NSCLC tends to have a more aggressive behavior compared to other forms of NSCLC. It has been associated with a higher risk of metastasis (spread to other body parts) and poorer prognosis. However, they are more commonly found in specific subgroups of patien...