Thelansis

  Linear IgA bullous dermatosis (LABD) is a rare acquired autoimmune subepithelial bullous disease characterized by linear deposition of IgA along the basement membrane zone (BMZ) targeting several autoantigens. The clinical presentation is heterogeneous and can mimic other blistering disorders such as dermatitis herpetiformis and bullous pemphigoid. However, characteristic cutaneous lesions consist of tense arciform bullae in a ‘string-of-pearls’ configuration. LABD can affect adults and children with similar histological and immunopathological features. LABD generally shows spontaneous resolution in children but not adults. Most cases of childhood LABD are idiopathic, but drugs and infections were reported as potential triggering factors. In adults, malignancies and influenza vaccination also may act as triggers. The child appeared restless and distressed by an intense itch. Lesional and perilesional biopsies were taken from the buttocks for histology and direct immunofluoresce...

 Linear IgA bullous dermatosis (LABD) is a rare acquired autoimmune subepithelial bullous disease characterized by linear deposition of IgA along the basement membrane zone (BMZ) targeting several autoantigens. The clinical presentation is heterogeneous and can mimic other blistering disorders such as dermatitis herpetiformis and bullous pemphigoid. However, characteristic cutaneous lesions consist of tense arciform bullae in a ‘string-of-pearls’ configuration. LABD can affect adults and children with similar histological and immunopathological features. LABD generally shows spontaneous resolution in children but not adults. Most cases of childhood LABD are idiopathic, but drugs and infections were reported as potential triggering factors. In adults, malignancies and influenza vaccination also may act as triggers. The child appeared restless and distressed by an intense itch. Lesional and perilesional biopsies were taken from the buttocks for histology and direct immunofluorescence...