Treatment-Resistant Depression (TRD) – Emerging Therapy, with Unmet Needs and TPP Insights Report – 2024 To 2034

Treatment-Resistant Depression (TRD) Emerging Therapy and TPP Insights

Thelansis’s “Treatment-Resistant Depression (TRD) Emerging Therapy, with Unmet Needs and TPP Insights Report – 2024 To 2034″ provides a comprehensive analysis of the emerging competitive landscape, unmet needs, target product profiles (TPPs), trial designs, and KOL insights on key emerging therapies and key drug development opportunities in the indication.

Treatment-Resistant Depression (TRD) Overview

Treatment-Resistant Depression (TRD) is a challenging subtype of major depressive disorder in which patients fail to respond adequately to at least two different antidepressants given at proper doses and durations, often leaving them with persistent symptoms such as low mood, fatigue, sleep disturbances, and cognitive impairment. The condition affects nearly a third of individuals with depression and may be influenced by genetic factors, comorbid psychiatric or medical conditions, and poor medication adherence. Diagnosis is clinical and requires careful assessment to rule out pseudo-resistance, while management involves a multimodal approach that may include switching or combining antidepressants, adding atypical antipsychotics or mood stabilizers, and exploring non-pharmacologic interventions such as cognitive behavioral therapy, electroconvulsive therapy, transcranial magnetic stimulation, or ketamine-based treatments. Emerging therapies like esketamine nasal spray and psychedelic-assisted psychotherapy are also being investigated for their potential to address the neurobiological complexity of TRD.

Geography coverage:

G8 (United States, EU5 [France, Germany, Italy, Spain, U.K.], Japan, and China)

Insights driven by surveys* with physician / key opinion leaders:

  • Survey findings are corroborated and enriched by insights from interviews with leading KOLs

*Survey is customized based on client requirements

Deliverables format:

  • PowerPoint presentation
  • MS Excel

Key business questions answered:

  • Detailed emerging competitive landscape
    • Pipeline analysis
    • Target patients for emerging therapies
    • Key companies
    • Key mechanism of actions
    • Launch date estimates, etc.
  • Clinical trial landscape analysis
    • Target patient segments
    • Trial endpoints
    • Trial design
    • Recruitment criteria, etc.
  • Unmet Needs and Opportunities
    • Performance of key current therapies
    • Top areas of unmet needs
    • Opportunity sizing for key unmet needs
  • Target Product Profiles
    • Attributes and levels
    • Physician likelihood of prescribing
    • Expected patient shares
  • KOL insights on key emerging therapies
    • Level of awareness
    • Expected use / line of therapy
    • Extent to fulfil key unmet needs
    • KOL quotes


Read more: Treatment-Resistant Depression (TRD) – Emerging Therapy, with Unmet Needs and TPP Insights Report – 2024 To 2034

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