Microsatellite Stable Colorectal Cancer – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

Microsatellite stability status in colorectal cancer is both a prognostic and a predictive biomarker that has significant importance in diagnosis and treatment. Microsatellite stability testing confirms whether the DNA segments have several or a few mutations. This helps determine the therapy and clinical practice, such as conventional chemotherapy drugs or immune checkpoint blockade with immunotherapy drugs, which may be more or less effective against a particular colorectal cancer. Colorectal cancer, commonly known as colon cancer, primarily arises in the colon or rectum; it is the third most prevalent form of cancer known for its slow progression over many years. Typically, it originates as a non-malignant polyp, an unusual tissue growth lining the colon. There are three main presentations of colorectal cancer: sporadic (70%), familial clustering (20%), and inherited syndrome (10%). Various risk factors are linked to the development of colon cancer, including age, environmental factors, diets high in animal fat, obesity, smoking, excessive alcohol consumption, genetic predisposition, and a history of inflammatory bowel disease. The most prevalent type of colon cancer diagnosed in patients is adenocarcinoma. Colorectal cancer development hinges on the adenoma-carcinoma sequence, characterized by a gradual accumulation of genetic alterations. In sporadic colorectal cancers, the gatekeeper pathway, governed by a gene that regulates growth, accounts for roughly 85% of cases and is the primary mechanism of carcinogenesis in individuals with familial adenomatous polyposis (FAP). A pivotal step in this process involves mutating the tumor-suppressor gene APC. Furthermore, several other tumor-suppressor genes (such as DCC, DPC4/Smad4, nm32, and p53) and oncogenes (e.g., c-myc, c-neu, c-src, c-erb-2, and K-ras) also play significant roles. Less common types of colon cancer include carcinoid tumors (which originate in hormone-producing cells in the intestines), gastrointestinal stromal tumors (a form of soft tissue sarcoma), and lymphoma (related to autoimmune conditions and capable of originating in the colon).

  • In 2023, it is anticipated that approximately 153,020 individuals in the United States will receive a colorectal cancer (CRC) diagnosis. Among this group, 19,550 individuals will be under the age of 50.

Thelansis’s “Microsatellite Stable Colorectal Cancer Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Microsatellite Stable Colorectal Cancer treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Microsatellite Stable Colorectal Cancer across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Microsatellite Stable Colorectal Cancer Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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