Liver Fibrosis – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

Liver fibrosis, an ineffective wound-healing process in the liver triggered by repeated and chronic injury from various causes such as infectious diseases (e.g., viral hepatitis), metabolic disorders (like nonalcoholic steatohepatitis), exposure to toxins (such as alcohol liver diseases), or autoimmune conditions (e.g., primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis), is characterized by the accumulation of extracellular matrix (ECM) produced by myofibroblasts. In healthy livers, myofibroblasts are absent but accumulate in response to injury, serving as the primary effector cells in fibrogenesis. Crucial events in the pathogenesis of liver fibrosis include hepatocyte damage triggering inflammatory reactions and the subsequent activation of hepatic stellate cells (HSCs), which in their quiescent state in normal livers store retinoids and function as pericytes for sinusoidal endothelial cells. In March 2024, the FDA approved Rezdiffra (resmetirom) as the inaugural drug specifically targeting nonalcoholic steatohepatitis (NASH) and liver fibrosis. Resmetirom, a thyroid hormone receptor beta-selective agonist, is available in 60 mg, 80 mg, and 100 mg.

  • The prevalence of liver fibrosis in the USA ranges from 3.9% to 7.5% of the adult population, with a notable escalation in risk with age, particularly in men and women in their 40s and 50s, respectively.

 

Thelansis’s “Liver Fibrosis Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Liver Fibrosis treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Liver Fibrosis across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Liver Fibrosis Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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