IDH1-Mutated Acute Myeloid Leukemia (AML) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

IDH1 mutations represent a subtype of genetic alterations observed in acute myeloid leukemia (AML), constituting approximately 20% of all AML cases. They are linked to poorer survival rates and a reduced likelihood of achieving complete remission. In younger adults with AML, IDH1 mutations occur in 6–10% of cases, while elderly patients exhibit a notably higher frequency of these mutations. Conversely, in pediatric AML cases, IDH mutations are rare, occurring in fewer than 4% of patients. These mutations drive the production of the oncometabolite 2-hydroxyglutarate, facilitating leukemogenesis by impeding normal myeloid differentiation processes. IDH1 inhibitors, oral small-molecule drugs, selectively target mutant IDH proteins to counteract this. Their mechanism involves inhibiting the production of 2-HG and promoting myeloid differentiation. IDH inhibitors can be administered alone or in conjunction with other therapies. Chronic exposure to certain chemicals significantly heightens the risk of developing AML, with benzene being the most extensively researched and commonly implicated leukemogenic agent. AML manifests as a malignant condition of the bone marrow characterized by the clonal expansion and inhibition of myeloid progenitor cell differentiation.

 

Thelansis’s “IDH1-Mutated Acute Myeloid Leukemia (AML) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential IDH1-Mutated Acute Myeloid Leukemia (AML) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of IDH1-Mutated Acute Myeloid Leukemia (AML) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

IDH1-Mutated Acute Myeloid Leukemia (AML) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: IDH1-Mutated Acute Myeloid Leukemia (AML) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

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