DiGeorge Syndrome (DGS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

DiGeorge syndrome (DGS) is a congenital disorder with a broad phenotypic presentation caused primarily by a microdeletion of chromosome 22 at 22q11.2. This mutation fails in the proper development of the pharyngeal pouches, which are responsible for the embryologic development of the middle and external ear, maxilla, palatine tonsils, mandible, thyroid, parathyroids, thymus, aortic arch, and cardiac outflow tract. DGS symptoms include cardiac anomalies, recurrent infections, abnormal facies, thymic hypoplasia or aplasia, cleft palate, developmental delay, and hypocalcemia. DGS symptoms include a thymus that is absent or hypoplastic, cardiac abnormalities, hypocalcemia, and parathyroid hypoplasia. The absence of thymic tissue, the organ responsible for T lymphocyte development, is the most concerning feature of DGS. A complete lack of the thymus, which is extremely rare and affects less than 1% of DGS patients, is associated with severe combined immunodeficiency (SCID). T-cells are specialized white blood cells specializing in immune functions such as destroying infected or malignant cells, acting as an integral part of the innate immune system by killing viruses, and assisting B-cells in maturing to produce immunoglobulins for stronger adaptive immunity. The degree of immunodeficiency in DGS patients can vary depending on the extent of thymic hypoplasia.

  • The most common microdeletion syndrome is 22q11.2 microdeletion, which affects about 0.1 percent of fetuses. The rate of 22q11.2 microdeletion in live births is estimated to be 1 in 4000 to 6000.

 

Thelansis’s “DiGeorge Syndrome (DGS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential DiGeorge Syndrome (DGS) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of DiGeorge Syndrome (DGS) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

DiGeorge Syndrome (DGS) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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