Activated PI3K Delta Syndrome (APDS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 Activated PI3K delta Syndrome (APDS), also referred to as PASLI disease, is a combined immunodeficiency that arises from dominant, gain-of-function mutations in the genes encoding p110δ (PIK3CD) and p85α (PIK3R1), the catalytic and regulatory subunits of phosphoinositide 3-kinase δ (PI3Kδ). This condition results in the hyperactivation of the PI3K/AKT/mTOR/S6K signaling pathways in immune cells. Patients with APDS can experience immune-deficient and immune-dysregulation features such as recurrent respiratory tract infections, bronchiectasis, herpesvirus infections, autoimmunity, non-neoplastic lymphoproliferation, and lymphoma, as well as neurodevelopmental delay and growth retardation. APDS1 and APDS2 are terms used to distinguish between APDS due to gain-of-function mutations in the genes encoding p110δ (PIK3CD) and p85α (PIK3R1), respectively. Unfortunately, there is currently no curative therapy available for APDS. However, certain treatment regimens can be implemented for APDS patients, such as antibiotic prophylaxis and immunoglobulin replacement therapy. Hematopoietic stem cell transplantation (HSCT) has proven to be successful in several APDS patients and may be a viable treatment option, especially in young patients.

·       Activated PI3K Delta Syndrome (APDS) incidence in the United States is approximately 1.75 to 2.3 patients per million population. Individuals with APDS often experience a wide range of inflammatory and autoimmune manifestations at a high frequency.

 

Thelansis’s “Activated PI3K Delta Syndrome (APDS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Activated PI3K Delta Syndrome (APDS) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Activated PI3K Delta Syndrome (APDS) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Activated PI3K Delta Syndrome (APDS) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Activated PI3K Delta Syndrome (APDS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Activated PI3K Delta Syndrome (APDS), Activated PI3K Delta Syndrome (APDS) market outlook, Activated PI3K Delta Syndrome (APDS) competitive landscape, Activated PI3K Delta Syndrome (APDS) market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

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