Propionic Acidemia (PA) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Propionic acidemia (PA) is a rare organic aciduria caused by a propionyl Coenzyme A carboxylase deficiency. This condition is characterized by severe metabolic decompensation, neurological dysfunction, and potential complications such as cardiomyopathy. PA can manifest in three distinct forms: severe neonatal onset, intermittent late onset, or a chronic progressive form. In the severe neonatal onset variant, affected infants display symptoms like poor feeding, vomiting, and altered sensorium within hours to weeks after birth. PA results from mutations in the PCCA and PCCB genes, which encode the propionyl CoA carboxylase subunits. Newborn screening tests identify PA through elevated propionyl carnitine levels, and differential diagnosis involves distinguishing it from other conditions like neonatal sepsis and other organic acidurias. In the infantile chronic form, symptoms can mimic those of cow milk intolerance, celiac disease, or immune deficiencies, including failure to thrive, chronic vomiting, and neutropenia. Early detection and treatment have improved survival rates in early and mid-childhood, although cognitive development impairment remains common. Hyperammonemia, a critical complication, can be managed with sodium benzoate, carbamyl glutamate, or hemodialysis. Long-term treatment primarily involves nutritional management, including protein restriction.

·       Propionic acidemia (PA) affects roughly 1 in 100,000 people in the United States.

 

Thelansis’s “Propionic Acidemia (PA) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Propionic Acidemia (PA) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Propionic Acidemia (PA) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Propionic Acidemia (PA) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Propionic Acidemia (PA) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Propionic Acidemia (PA), Propionic Acidemia (PA) market outlook, Propionic Acidemia (PA) competitive landscape, Propionic Acidemia (PA) market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

 

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