Doose Syndrome – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

Doose Syndrome, formerly known as Myoclonic Astatic Epilepsy and Myoclonic Atonic Epilepsy, is an extremely uncommon form of seizures that impacts young children in their early years. Various types of seizures characterize this syndrome. Myoclonic seizures involve rapid jerking movements that can manifest in the trunk or axis of the body. Sometimes, these jerks can lead to a myoclonic drop, where the individual appears to be forcefully propelled to the ground. There can also be subtler jerks perceived subjectively by the child or expressed through subtle vocalizations. Astatic or atonic seizures are possible, causing momentary loss of muscle tone, often resulting in head nodding. However, the child typically regains balance swiftly, preventing a complete fall. Children afflicted by Doose Syndrome can experience long-term health repercussions, including physical injuries and respiratory challenges. Immediate medical attention might also be necessary. Distinguishing between Doose syndrome and other seizure disorders like benign myoclonic epilepsy, severe myoclonic epilepsy, atypical benign partial epilepsy of childhood, and Lennox-Gastaut Syndrome (LGS). Severe myoclonic epilepsy (Dravet syndrome) is notably separate from Doose syndrome. Even though both might commence with febrile seizures in cognitively normal children, Dravet syndrome often involves partial seizures and distinctive EEG focal findings absent in Doose syndrome. Unlike Doose syndrome, severe myoclonic epilepsy prominently features myoclonus and rarely includes an atonic element. Historically, Doose syndrome has been recognized as difficult to manage effectively. The prognosis for Doose syndrome can vary, leaning toward favorable or unfavorable outcomes. The unfavorable prognosis in Doose syndrome is marked by generalized tonic-clonic seizures in the first two years of life, early development of myoclonic status, absence or convulsive status epilepticus, tonic seizures, persistent abnormal theta rhythm in the background, and absence of a background alpha rhythm. Poor prognosis indicators also encompass sleep-onset seizures and the emergence of myoclonic seizures after age four, suggesting continued excitatory pathway activity. In children with a grim prognosis, cognitive impairment tends to align with resistance to anticonvulsants and the ketogenic diet.

  • The prevalence of Doose Syndrome is remarkably low, typically affecting only 1 to 2 out of every 100 children diagnosed with epilepsy. Moreover, boys are more prone to developing Doose Syndrome compared to girls.

Thelansis’s “Doose Syndrome Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Doose Syndrome treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Doose Syndrome across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Doose Syndrome Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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