Waldenstrom Macroglobulinemia (WM) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder characterized by the accumulation of monoclonal cells in both the bone marrow and peripheral lymphoid tissues. WM condition is associated with producing a monoclonal protein known as serum immunoglobulin M (IgM). While the exact cause of WM remains unknown, it is believed to have immune-related factors involved, and there is a clear familial connection, as first-degree relatives of WM patients are at an increased risk of developing the disease. While specific susceptibility genes have not yet been pinpointed, susceptibility loci have been identified on chromosome 6p21.3 and 4q. In addition, approximately half of WM patients exhibit 6q deletions on their tumor cells. WM is typically diagnosed at a median age of 72 and is twice as common in men as in women. The primary clinical manifestations include hepatosplenomegaly, lymphadenopathy, constitutional symptoms, oronasal bleeding, hyperviscosity syndrome, and cytopenia. Fatigue resulting from normochromic normocytic anemia is the most frequently reported initial symptom. While visceral infiltration is uncommon, it may affect organs such as the stomach, small bowel, lungs, exocrine glands, or skin, leading to symptoms like diarrhea, steatorrhea, and skin purpura. In cases involving hyperviscosity syndrome, there is a risk of retinal hemorrhage or severe neurologic complications, such as mental confusion or stroke. Peripheral neuropathy is present in up to 38% of WM patients, and in a few cases, nephrotic syndrome has been linked to WM. Significant complications include bone marrow failure, autoimmune cytopenia, large B-cell lymphoma, immune complex vasculitis, and infection susceptibility. The diagnosis of WM is confirmed through the presence of an IgM monoclonal protein in the serum and a bone marrow biopsy that reveals ≥10% clonal lymphoplasmacytic cells. Differential diagnoses include multiple myeloma, B-cell chronic lymphocytic leukemia, other forms of non-Hodgkin lymphoma, and monoclonal gammopathies of undetermined significance. The FDA recently approved zanubrutinib (BRUKINSA, BeiGene) as a treatment option for adult patients with Waldenstrom macroglobulinemia (WM).

 

·       In the United States, the incidence of WM is higher among males, with an annual rate of 0.34 cases per 100,000, compared to females, who have an annual rate of 0.17 cases per 100,000.

·       The median survival time after initiating treatment for WM is approximately 5-6 years, although the disease can remain stable or progress slowly for many years before necessitating treatment.

 

Thelansis’s “Waldenstrom Macroglobulinemia (WM) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Waldenstrom Macroglobulinemia (WM) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Waldenstrom Macroglobulinemia (WM) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Waldenstrom Macroglobulinemia (WM) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Waldenstrom Macroglobulinemia (WM) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Waldenstrom Macroglobulinemia (WM), Waldenstrom Macroglobulinemia (WM) market outlook, Waldenstrom Macroglobulinemia (WM) competitive landscape, Waldenstrom Macroglobulinemia (WM) market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

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