Myelodysplastic Syndromes (MDS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 Myelodysplastic syndrome (MDS) comprises a group of myeloid hematological disorders distinguished by reduced blood cell counts, abnormalities in the bone marrow, and a significant risk of evolving into acute myeloid leukemia (AML). Clinical manifestations primarily result from low blood cell counts, predominantly anemia, leading to fatigue, shortness of breath, and potentially angina. Less frequently, MDS may manifest as thrombocytopenia, resulting in spontaneous bleeding or neutropenia, making individuals susceptible to bacterial or, in rarer cases, fungal infections. The underlying cause remains unknown in 80% of cases. In the remaining 20%, it may be attributed to acquired factors such as prior chemotherapy or radiation therapy, occupational exposure to benzene derivatives or ionizing radiation, or inherited factors, including gene mutations mainly involving DDX41, GATA2, RUNX, and telomerase genes, or DNA instability (notably seen in Fanconi anemia patients who are prone to developing MDS). MDS progresses into AML in approximately 30% of patients. The prognosis varies depending on several criteria evaluated using the IPSS-R and IPSS-M scoring systems. These criteria consider the number and significance of cytopenias, the percentage of blasts in the bone marrow, and cytogenetic abnormalities in the marrow. These scores categorize patients into lower-risk groups (primarily characterized by anemia and, less frequently, thrombocytopenia) and higher-risk groups (typically featuring severe cytopenias, including neutropenia). These categories are divided into five (IPSS-R) or six (IPSS-M) levels, ranging from very low risk (with a 2.8% risk of progressing to AML within four years) to very high risk (with a 42.8% risk of AML transformation within four years). The risk of developing MDS increases with age, with approximately 86% of newly diagnosed MDS patients in the United States being 60 years old on average (median age: 76 years). Management and treatment strategies are determined based on the prognostic score calculated using the revised International Prognostic Scoring System for Myelodysplastic Syndromes (IPSS-R).

·       The incidence of MDS patients eligible for second-line therapy is estimated at 3 per 100,000 individuals, suggesting that approximately 9,500 people in the United States may be suitable candidates for second-line therapy for MDS annually.

 

Thelansis’s “Myelodysplastic Syndromes (MDS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Myelodysplastic Syndromes (MDS) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Myelodysplastic Syndromes (MDS) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Myelodysplastic Syndromes (MDS) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Myelodysplastic Syndromes (MDS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes (MDS) market outlook, Myelodysplastic Syndromes (MDS) competitive landscape, Myelodysplastic Syndromes (MDS) market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

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