Progressive Multifocal Leukoencephalopathy (PML) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032

Progressive multifocal leukoencephalopathy (PML) is a rare, fatal demyelinating disease of the central nervous system (CNS) caused by the JC virus (JCV) that occurs in patients with weakened immune systems. Initial infection with JC virus (JCV) through ingestion or inhalation of virion particles might lead to subacute infection and stimulation of antiviral antibodies. JCV can infect the uroepithelium of the kidney and establish a persistent or latent infection and might escape into the peripheral circulation, spreading virions into lymphoid tissues and showing a latent infection that can be reactivated at times of immune suppression or modulation. PML develops in patients with underlying neoplastic diseases, mostly lymphoproliferative diseases, and in patients with organ transplants who have undergone immune suppression for graft protection. JCV has a narrow cellular host range and a variable effect on the organs it infects. Infection in human endothelial cells in the kidney and in cells of haematopoietic lineages, such as CD34+ cells, B-cell phenotypes, CD19+ cells, and CD20+ cells, has no known pathological effects, making host infection a silent event. In the brain, however, multiplication in oligodendrocytes is lytic and causes Progressive multifocal leukoencephalopathy (PML) with devastating clinical consequences, including progressive motor dysfunction, cognitive impairment, and visual deficits. Infection of neurons in the granular cell layer of the cerebellum can also cause symptomatic neuronopathy.

·       The incidence of Progressive multifocal leukoencephalopathy (PML) ranges from 1 to 2 cases per 200,000 population in the USA.

Thelansis’s “Progressive Multifocal Leukoencephalopathy (PML) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Progressive Multifocal Leukoencephalopathy (PML) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Progressive Multifocal Leukoencephalopathy (PML) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Progressive Multifocal Leukoencephalopathy (PML) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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