Doose Syndrome – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032
Doose Syndrome, formerly known as
Myoclonic Astatic Epilepsy and Myoclonic Atonic Epilepsy, is an extremely
uncommon form of seizures that impacts young children in their early years.
Various types of seizures characterize this syndrome. Myoclonic seizures
involve rapid jerking movements that can manifest in the trunk or axis of the
body. Sometimes, these jerks can lead to a myoclonic drop, where the individual
appears to be forcefully propelled to the ground. There can also be subtler
jerks perceived subjectively by the child or expressed through subtle
vocalizations. Astatic or atonic seizures are possible, causing momentary loss
of muscle tone, often resulting in head nodding. However, the child typically
regains balance swiftly, preventing a complete fall. Children afflicted by
Doose Syndrome can experience long-term health repercussions, including
physical injuries and respiratory challenges. Immediate medical attention might
also be necessary. Distinguishing between Doose syndrome and other seizure disorders
like benign myoclonic epilepsy, severe myoclonic epilepsy, atypical benign
partial epilepsy of childhood, and Lennox-Gastaut Syndrome (LGS). Severe
myoclonic epilepsy (Dravet syndrome) is notably separate from Doose syndrome.
Even though both might commence with febrile seizures in cognitively normal
children, Dravet syndrome often involves partial seizures and distinctive EEG
focal findings absent in Doose syndrome. Unlike Doose syndrome, severe
myoclonic epilepsy prominently features myoclonus and rarely includes an atonic
element. Historically, Doose syndrome has been recognized as difficult to
manage effectively. The prognosis for Doose syndrome can vary, leaning toward
favorable or unfavorable outcomes. The unfavorable prognosis in Doose syndrome
is marked by generalized tonic-clonic seizures in the first two years of life,
early development of myoclonic status, absence or convulsive status
epilepticus, tonic seizures, persistent abnormal theta rhythm in the
background, and absence of a background alpha rhythm. Poor prognosis indicators
also encompass sleep-onset seizures and the emergence of myoclonic seizures
after age four, suggesting continued excitatory pathway activity. In children
with a grim prognosis, cognitive impairment tends to align with resistance to
anticonvulsants and the ketogenic diet.
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The prevalence of Doose Syndrome is remarkably
low, typically affecting only 1 to 2 out of every 100 children diagnosed with
epilepsy. Moreover, boys are more prone to developing Doose Syndrome compared
to girls.
Thelansis’s “Doose Syndrome Market
Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022
To 2032" covers disease overview, epidemiology, drug utilization,
prescription share analysis, competitive landscape, clinical practice,
regulatory landscape, patient share, market uptake, market forecast, and key
market insights under the potential Doose Syndrome treatment modalities options
for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and
China).
KOLs insights
of Doose Syndrome across 8 MM market from the centre of Excellence/ Public/
Private hospitals participated in the study. Insights around current treatment
landscape, epidemiology, clinical characteristics, future treatment paradigm,
and Unmet needs.
Doose Syndrome Market Forecast Patient
Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs
with sourcing, Market Event, and Product Event, Country specific Forecast
Model, Market uptake and patient share uptake, Attribute Analysis, Analog
Analysis, Disease burden, and pricing scenario, Summary, and Insights.
Thelansis Competitive Intelligence (CI) practice
has been established based on a deep understanding of the pharma/biotech
business environment to provide an optimized support system to all levels of
the decision-making process. It enables business leaders in forward-thinking
and proactive decision-making. Thelansis supports scientific and commercial
teams in seamless CI support by creating an AI/ ML-based technology-driven
platform that manages the data flow from primary and secondary sources.
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