Ataxia Telangiectasia (AT) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032


 Ataxia telangiectasia, also known as Louis-Bar syndrome, is a rare genetic form of early-onset autosomal recessive ataxia resulting from mutations in the ataxia telangiectasia mutated (ATM) gene located on chromosome 11q22-23. The disease is characterized by a combination of neurological and systemic symptoms, including cerebellar atrophy with progressive ataxia, cutaneous telangiectasias, a higher incidence of malignancy (particularly lymphoid malignancy), radiosensitivity, immune deficiency, recurrent sinopulmonary infections, and high levels of alpha-fetoprotein in serum. The impairment of cells to respond to different pathogenic triggers, such as ionizing radiation and alkylating agents, is due to the ATM gene mutation, leading to aberrant repair of the breaks of double-strand DNA. This defect results in cell death in susceptible tissues, such as the cerebellum, and malignant proliferation. Nonsense, frameshift, missense, and insertion-deletion mutations of the ATM gene associated with A-T have been described, with the majority leading to a nonfunctional protein. Some other neurologic disorders, such as ataxia-telangiectasia-like disorder 2 (ATLD2), RIDDLE syndrome (RNF168 deficiency), ataxia oculomotor apraxia type 1 (AOA1), ataxia oculomotor apraxia type 2 (AOA2), Friedreich’s ataxia and spinocerebellar ataxia with axonal neuropathy (SCAN1), may be misdiagnosed as A-T based on similar clinical and laboratory features, especially those with childhood-onset ataxia that might be misdiagnosed with incomplete forms of A-T.

·       The global prevalence of Ataxia telangiectasia (AT) is estimated to range from 1 in 40,000 to 1 in 100,000 live births\

Thelansis’s “Ataxia Telangiectasia (AT) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Ataxia Telangiectasia (AT) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Ataxia Telangiectasia (AT) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Ataxia Telangiectasia (AT) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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