Lecithin-Cholesterol Acyltransferase (LCAT) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032


 Lecithin-cholesterol acyltransferase (LCAT) deficiency is an autosomal recessive disorder characterized by very low high-density lipoprotein (HDL) cholesterol levels but a remarkably variable and often low frequency of cardiovascular disease in carriers. The phenotype is milder than that seen in total LCAT deficiency. The phenotypic differences between LCAT deficiency and fisheye disease have been attributed to whether LCAT gene mutations encode variants that fail to esterify HDL cholesterol and apoB-containing lipoproteins (LCAT deficiency) or HDL only. The clinical characteristics include corneal opacities, splenomegaly, normocytic normochromic anemia, low HDL and α-lipoprotein levels, and elevated LDL levels. The fisheye disease also can exist without anemia, splenomegaly, or renal disease. Likely, the accumulation in plasma of a cholesterol-rich multilamellar particle called lipoprotein-X is pathogenic in the kidneys. Proteinuria, including nephrotic syndrome, progressive renal failure, and hypertension, are the main renal manifestations. On light microscopy, intimal hyperplasia, the glomeruli have foam cells and thickening of the GBM with effacement of the foot processes.

  • The global prevalence of Lecithin-cholesterol acyltransferase (LCAT) deficiency ranges from 0.75 to 1.15 per million cases.

Thelansis’s “Lecithin-Cholesterol Acyltransferase (LCAT) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Lecithin-Cholesterol Acyltransferase (LCAT) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Lecithin-Cholesterol Acyltransferase (LCAT) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Lecithin-Cholesterol Acyltransferase (LCAT) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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