Rhabdomyosarcoma (RMS) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. RMS can occur anywhere in the body, including the head and neck, genitourinary organs, extremities, and abdomen. Although still debated, evidence suggests that RMS arises from the mesenchymal cell lineage, which is typically fated to become skeletal muscle tissue. RMS is traditionally classified into two major histological subtypes, embryonal RMS (ERMS) and alveolar RMS (ARMS), of which 60–70% of cases are ERMS and 20–30% are ARMS. 80% of ARMS cases are defined by a chromosomal translocation between PAX3 or PAX7 and FOXO1 genes; these translocations result in fusion genes that primarily drive oncogenic activity. The other 20% of ARMS cases are similar to ERMS in terms of clinical outcomes and the pattern of somatic mutations. Despite the clinical significance of RMS, the underlying etiologies remain the environmental and genetic factors individually contribute to this malignancy.

 

Approximately 50% of all pediatric soft-tissue sarcoma diagnoses are Rhabdomyosarcoma, with an incidence of roughly 4.71 per million children and adolescents less than 20 years of age in the United States.

 

The competitive landscape includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Rhabdomyosarcoma (RMS) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Rhabdomyosarcoma (RMS) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Rhabdomyosarcoma (RMS) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Lymphoseek®   Cardinal Health 414, LLC           Phase 2

2          Lipegfilgrastim   Merckle GmbH  Phase 1

3          Afatinib Boehringer Ingelheim     Phase 2

4          IMX-110           Immix Biopharma, Inc.   Phase 2

5          Regorafenib (BAY73-4506)        Bayer   Phase 2

6          Doxorubicin Hydrochloride         Novartis Pharmaceuticals            Phase 1

7          JX-594  Jennerex Biotherapeutics           Phase 1

8          Temozolomide  Pfizer    Phase 2

9          Cabozantinib     Exelixis Phase 2

10        Gemcitabine     Celgene Corporation     Phase 1

Continued
 

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