Hyperoxaluria – Market outlook, Epidemiology, Competitive Landscape and Market Forecast Report – 2020 To 2030

Hyperoxaluria results from excessive dietary intake (dietary oxaluria), gastrointestinal disorders or surgery that lead to excess oxalate absorption (enteric oxaluria), or rarely an enzyme deficiency that results in excessive production of oxalate (PHO).

 

Etiology-

Hyperoxalurias can be broadly divided into primary and secondary based on their etiology:

 

Primary hyperoxaluria is caused by an inherent defect or absence of enzyme activity, ultimately leading to increased levels of oxalate in the body.

·       Primary hyperoxaluria type 1: Glyoxalate is produced as an intermediate molecule in the metabolism of hydroxyproline, glycolate, and glycine and is generally detoxified in the peroxisome of the hepatocytes by the enzyme alanine:glyoxylate-aminotransferase (AGT), which converts glyoxalate to glycine.

·       Primary hyperoxaluria type 2: On chromosome 10, the gene GRHPR codes for the enzyme glyoxalate/ hydroxypyruvate reductase (GRHPR). This enzyme converts glyoxalate to glycolate. A deficiency of this enzyme will lead to a buildup of glyoxalate and eventually oxalate.

·       Primary hyperoxaluria type 3: This is the least common type, wherein a deficiency of enzyme mitochondrial 4-hydroxy 2-oxoglutarate aldolase coded by the gene HOGA1 on chromosome 9 fails to convert 4-hydroxy 2-oxoglutarate into glyoxalate.

Secondary hyperoxaluria mainly pertains to excess exogenous oxalate gained either through diet or due to intestinal pathologies.

 

Epidemiology-

In 2012 a survey suggested that in the United States, approximately 1 out of 11 people suffered from renal stones.

 

The competitive landscape of Hyperoxaluria includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are being tracked and supplemented with analyst commentary.

KOLs insights of Hyperoxaluria across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Hyperoxaluria Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Hyperoxaluria – Market outlook, Epidemiology, Market Forecast and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Lumasiran         Alnylam Pharmaceuticals           Phase 2/3

2          stiripentol (Diacomit)      Biocodex           Phase 2

3          Oxabact            OxThera           Phase 3

4          nedosiran          Dicerna Pharmaceuticals, Inc.    Phase 2

5          Reloxaliase       Allena Pharmaceuticals Phase 3

6          SYNB8802        Synlogic            Phase 1

7          NOV-001          Novome Biotechnologies Inc      Phase 2

 

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