Hemorrhagic Cystitis (HC) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030
Hemorrhagic cystitis (HC) is a diffuse inflammatory condition of the urinary system due to an infectious or noninfectious reason resulting in bleeding from the bladder mucosa. The most common cause is a bacterial infection that responds promptly to treatment. However, chronic and recurrent hemorrhagic cystitis often arises from chemotherapy, radiotherapy, or HSCT treatment. HC is manifested in two forms: early-onset HC, which usually appears within 48–72 h following chemotherapy, and late-onset HC, which occurs during the first 2–3 months after HSCT. Early-onset HC has been associated mainly with cyclophosphamide and busulfan administration. These drugs can damage the uroepithelium directly or through their metabolites. Late-onset HC to be associated with virus reactivation in immune-compromised patients. The main treatment recommendations are based on supportive measures such as hyperhydration, forced diuresis, and continuous bladder irrigation. The chronic form of HC defined Grade I-gross hematuria and thrombocytopenia; Grade II - gross hematuria and clots; Grade III- gross hematuria, clots, and urethral obstruction.
Hemorrhagic
cystitis (HC) varies between 20% to 55% in all chemotherapy or radiotherapy or HSCT-treated
patient pools.
The competitive
landscape of Hemorrhagic Cystitis (HC) includes country-specific approved and
pipeline therapies. Any asset/product-specific designation or review and
Accelerated Approval are tracked and supplemented with analyst commentary.
KOLs insights of Hemorrhagic
Cystitis (HC) across 8 MM market from the center of Excellence/ Public/ Private
hospitals participated in the study. Insights around current treatment
landscape, epidemiology, clinical characteristics, future treatment paradigm,
and Unmet needs.
Hemorrhagic
Cystitis (HC) Market
Forecast: Patient Based Forecast Model (MS. Excel Based Automated
Dashboard) which Data Inputs with sourcing, Market Event, and Product Event,
Country specific Forecast Model, Market uptake and patient share uptake,
Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario,
Summary, and Insights.
S. No Asset Company Stage
1 LP-10 Lipella
Pharmaceuticals, Inc. Phase 2
2 Posoleucel (ALVR105) AlloVir Phase 3
3 activated recombinant human factor VII Novo Nordisk A/S Phase 2
4 Cidofovir Gilead
Sciences Phase 1

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