Cold Agglutinin Disease (CAD) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030

Cold agglutinin disease (CAD), also known as primary or idiopathic CAD, is a clonal B-cell lymphoproliferative disorder of the bone marrow that results in autoimmune hemolytic anemia (AIHA). CAD predominantly affects elderly or middle-aged people. IGHV4-34 almost exclusively encodes CAD antibodies; in rare instances, anti-I cold agglutinins may also be encoded by IGHV3 family genes. Cold agglutinins associated with CAD are monoclonal and most often of the immunoglobulin M (IgM) class with κ light-chain restriction. After an IgM cold agglutinin binds to its antigen on the erythrocyte surface, complement is activated by the classical pathway, and complement activation is essential for hemolysis. Most effective therapies have aimed to target the pathogenic B-cell clone. Currently, however, novel complement-directed therapies are being rapidly developed.

 

The estimated incidence of Cold agglutinin disease (CAD) varies 0.8 to 3 per 100,000 population per year, and the prevalence is 15 to 20 per 100,000 population in the USA.

 

The competitive landscape includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Cold Agglutinin Disease (CAD) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Cold Agglutinin Disease (CAD) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Cold Agglutinin Disease (CAD) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Pegcetacoplan  Swedish Orphan Biovitrum         Phase 3

2          Eculizumab       Alexion Pharmaceuticals            Phase 2

3          BIVV020           Bioverativ, a Sanofi company     Phase 3

4          Iptacopan         Novartis Pharmaceuticals          Phase 2

 

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