APOE4 homozygous Alzheimer’s disease (AD) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030


 Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with cognitive decline and is the most common form of dementia in the elderly. Approximately 13% of people over the age of 65 and 45% over the age of 85 are estimated to have AD. The imbalance between the production and clearance of amyloid-β (Aβ) peptides in the brain results in the accumulation and aggregation of Aβ. The toxic Aβ aggregates in the form of soluble Aβ oligomers, intraneuronal Aβ, and amyloid plaques injure synapses and ultimately cause neurodegeneration and dementia. The toxicity of Aβ seems to depend on the presence of microtubule-associated protein tau, the hyperphosphorylated forms of which aggregate and deposit in AD brains as neurofibrillary tangles. Aβ is composed of 40 or 42 amino acids and is generated through proteolytic cleavage of the amyloid precursor protein. Early-onset familial AD, which typically develops before the age of 65 years and accounts for only a tiny portion (<1%) of AD cases, is primarily caused by overproduction of Aβ owing to mutations in either the APP gene or genes encoding presenilin 1 (PSEN1) or presenilin 2 (PSEN2), essential components of the γ-secretase complexes responsible for cleavage and release of Aβ.

The ε4 allele of the apolipoprotein E (APOE) gene is the most potent risk factor for LOAD.

The human APOE gene exists as three polymorphic alleles, ε2, ε3, and ε4, with a worldwide frequency of 8.4%, 77.9%, and 13.7%, respectively. However, the frequency of the ε4 allele is dramatically increased to ~40% in patients with AD.

 

The competitive landscape of APOE4 homozygous Alzheimer’s disease (AD) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of APOE4 homozygous Alzheimer’s disease (AD) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

APOE4 homozygous Alzheimer’s disease (AD) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: APOE4 homozygous Alzheimer’s disease (AD) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          LX1001 Lexeo Therapeutics       Phase 1

2          ALZ-801           Alzheon Inc.      Phase 3

3          Obicetrapib       NewAmsterdam Pharma            Phase 2

4          Tricaprilin          Cerecin Phase 3

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