Osteogenesis Imperfecta (OI) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

Osteogenesis Imperfecta (OI), or brittle bone disease, is a genetic disorder affecting connective tissues due to abnormalities in the synthesis or processing of type I collagen. This condition leads to increased susceptibility to bone fractures and reduced bone density. Other symptoms include blue sclerae, dentinogenesis imperfecta, short stature, and adult-onset deafness. Reports also indicate valvular insufficiencies and aortic root dilation. Milder symptoms include generalized laxity, easy bruising, hernias, and excessive sweating. Clinical manifestations range from nearly asymptomatic forms to severe cases (such as infants with crumpled ribs, fragile cranium, and long bone fractures incompatible with life) that increase perinatal mortality. OI is a rare genetic disease, often stemming from mutations in the COL1A1 and COL1A2 genes. The International Society of Skeletal Dysplasias classifies OI based on the mode of inheritance and genes involved:

Osteogenesis Imperfecta Type

Inheritance

Genes

Nondeforming OI (Type I)

AD, X-linked

COL1A1, COL1A2, PLS3

Perinatal (Type II)

AD, AR

COL1A1, COL1A2, CRTAP, LEPRE1, PPIB, BMP1

Progressively Deforming (Type III)

AD, AR

COL1A1, COL1A2, CRTAP, LEPRE1, PPIB, FKBP10, SERPINH1, SERINF1, WNT1

Moderate (Type IV)

AD, AR

COL1A1, COL1A2, CRTAP, FKBP10, SP7, SERPINF1, WNT1, TMEM38B

Calcification of Interosseous Membrane or Hypertrophic Callus (Type V)

AD

IFITM5


Management varies according to the age, severity, and functional status of patients:

  • Mild disease: Subtle restriction, avoid contact sports, treatment for any fractures.
  • Moderate to Severe disease: Rehabilitation and orthopedic interventions, management of acute fractures and scoliosis.
  • Severe disease: Use of an intramedullary rod with osteotomy to correct severe bowing of long bones.

 

Thelansis’s “Osteogenesis Imperfecta (OI) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Osteogenesis Imperfecta (OI) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Osteogenesis Imperfecta (OI) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Osteogenesis Imperfecta (OI) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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