Acne Vulgaris – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

 

Acne vulgaris, a prevalent pilosebaceous unit inflammatory skin disorder, follows a persistent course. Typically presenting as papules, pustules, or nodules, it primarily occurs on the face but can also impact the upper arms, trunk, and back. The development of acne results from the sebaceous glands' heightened sensitivity to normal androgen levels, aggravated by Cutibacterium acnes (formerly known as Propionibacterium acnes), a bacterial species that triggers inflammation. The pathogenesis of acne vulgaris involves a complex interplay of factors such as the activation of sebaceous glands by androgens, imbalances in the pilosebaceous follicle microbiome, and cellular immune responses. Genetic predisposition and dietary influences also contribute to the condition's onset and progression. The initial stage is the micro-comedo, a small plug primarily composed of corneocytes in the lower follicular infundibulum. Microcomedones evolve into various acne lesions, including closed comedones (whiteheads), open comedones (blackheads), and inflammatory papules, pustules, and nodules. This progression is believed to be driven by four main pathogenic events:

·       Increased sebum production (seborrhea)

·       Follicular hyperkeratinization

·       Presence of C acnes

·       Inflammation

For patients diagnosed with acne fulminans, a comprehensive assessment, including blood tests like complete blood count, liver function tests, erythrocyte sedimentation rate, and C-reactive protein, is recommended. The primary treatment for mild acne vulgaris involves topical therapy, often using topical retinoids, antibiotics, and benzoyl peroxide. The differential diagnoses for acne vulgaris encompass a broad range, including:

·       Distinguishing rosacea from acne involves noting the absence of comedones and the presence of telangiectasia.

·       Perioral dermatitis is marked by erythematous papules around the mouth, unlike acne vulgaris.

·       Demodex folliculitis is suspected when standard acne or rosacea treatments fail to work, causing inflammatory papules and pustules.

·       Facial angiofibroma in tuberous sclerosis is visible as pink or red papules on the cheeks and nose, typically in children.

·       Pseudofolliculitis barbae appears as inflammatory papules, pustules, and scarring in the beard area of individuals with tightly curved hair.

Overall, with proper treatment, acne has a favorable prognosis. Although not life-threatening, it can have enduring psychological impacts, causing heightened anxiety and depression, particularly for those with scars. The complications associated with acne vulgaris encompass: - Psychological effects, including lowered self-esteem, depression, and anxiety, either due to visible skin changes during flare-ups or disfiguring scars.

·       Acne is the most prevalent skin condition in the United States, affecting approximately 50 million Americans annually.

Thelansis’s “Acne Vulgaris Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Acne Vulgaris treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Acne Vulgaris across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Acne Vulgaris Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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