X-linked Adrenoleukodystrophy (X-ALD) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

Adrenoleukodystrophy (ALD), also known as X-linked adrenoleukodystrophy (X-ALD), is the most common peroxisomal disorder. It is distinguished by impaired peroxisomal beta-oxidation of very long-chain fatty acids, which is reduced to about 30% of control levels. Because of mutations in the ABCD1 gene, which encodes the peroxisomal membrane protein ALDP, VLCFA accumulates in the plasma and all tissues, including the brain's white matter, the spinal cord, and the adrenal cortex. In males with X-ALD, the clinical spectrum ranges from isolated adrenocortical insufficiency and slowly progressive myelopathy to devastating cerebral demyelination. By the age of 60, the majority of heterozygous females will have symptoms. The disease course remains unpredictable in individual patients. Based on lipid inclusions in adrenal glands, brain and Schwann cells, testis, Schaumburg, and Powers suggested the term adrenoleukodystrophy for the disorder. Adrenocortical insufficiency can be the presenting symptom of X-ALD in boys and men years or even decades before neurological symptoms appear. X-ALD is a common cause of Addison's disease in boys and adult males, particularly when circulating adrenocortical auto is remarkably absent.

  • The diagnosed incidence of X-linked adrenoleukodystrophy (X-ALD) varies between 1 to 1.5 cases per 15,000 to 20,000 live birth population in the USA.

 

Thelansis’s “X-linked Adrenoleukodystrophy (X-ALD) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential X-linked Adrenoleukodystrophy (X-ALD) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of X-linked Adrenoleukodystrophy (X-ALD) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

X-linked Adrenoleukodystrophy (X-ALD) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: X-linked Adrenoleukodystrophy (X-ALD) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

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