Hypoplastic Left Heart Syndrome (HLHS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 Hypoplastic Left Heart Syndrome (HLHS) is a multifaceted cardiac malformation, likely originating from numerous developmental errors during the initial stages of cardiogenesis. If not treated, it is invariably fatal. HLHS is characterized by an array of chest radiographic findings, including an enlarged cardiac silhouette (with a notably prominent right atrium), pulmonary venous hypertension, an atrial septal defect, and valvular stenosis or atresia. In patients with HLHS, pulmonary venous blood enters the left atrium, but the atretic or stenotic mitral valve prevents the atrial systole from pushing blood into the hypoplastic left ventricle. HLHS predominantly affects males and is known to have a genetic predisposition in certain families. However, the complete genetic etiology remains elusive—approximately 12% of infants with HLHS present with associated extracardiac anomalies. Genetic disorders linked with HLHS include Turner syndrome, Holt-Oram syndrome, Smith-Lemli-Opitz syndrome, Noonan syndrome, and trisomies 13, 18, and 21. The left atrial blood is diverted across interatrial communication, ranging from a highly restrictive foramen ovale to a wide, nonrestrictive atrial septal defect. The most common scenario involves a restrictive foramen ovale that limits left-to-right shunting. This limited flow, combined with reduced flow through the mitral valve, results in pulmonary venous outflow obstruction, leading to the typical presentation of a neonate with severe congestive heart failure. The standard treatment involves open-heart surgery to redirect the oxygen-rich (“red”) and oxygen-poor (“blue”) blood. The “Staged Reconstruction,” a series of three reconstructive operations — the Norwood, Glenn, and Fontan procedures — is employed to repair HLHS.

·       HLHS has a reported prevalence of 0.2 per 1,000 live births and is twice as common in boys as in girls. If left untreated, HLHS is invariably lethal, accounting for 25% of early cardiac deaths in neonates.

 

Thelansis’s “Hypoplastic Left Heart Syndrome (HLHS) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Hypoplastic Left Heart Syndrome (HLHS) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Hypoplastic Left Heart Syndrome (HLHS) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Hypoplastic Left Heart Syndrome (HLHS) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Hypoplastic Left Heart Syndrome (HLHS) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Hypoplastic Left Heart Syndrome (HLHS), Hypoplastic Left Heart Syndrome (HLHS) market outlook, Hypoplastic Left Heart Syndrome (HLHS) competitive landscape, Hypoplastic Left Heart Syndrome (HLHS) market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

Comments

Post a Comment

Popular posts from this blog

Acne Vulgaris – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Image
  Acne vulgaris, a prevalent pilosebaceous unit inflammatory skin disorder, follows a persistent course. Typically presenting as papules, pustules, or nodules, it primarily occurs on the face but can also impact the upper arms, trunk, and back. The development of acne results from the sebaceous glands' heightened sensitivity to normal androgen levels, aggravated by Cutibacterium acnes (formerly known as Propionibacterium acnes), a bacterial species that triggers inflammation. The pathogenesis of acne vulgaris involves a complex interplay of factors such as the activation of sebaceous glands by androgens, imbalances in the pilosebaceous follicle microbiome, and cellular immune responses. Genetic predisposition and dietary influences also contribute to the condition's onset and progression. The initial stage is the micro-comedo, a small plug primarily composed of corneocytes in the lower follicular infundibulum. Microcomedones evolve into various acne lesions, including closed co...
Read more

Herpes Simplex Virus (HSV) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Image
 Herpes simplex virus (HSV) causes an infection that affects the external genitalia, anal region, mucosal surfaces, and skin in other body parts. Herpes simplex virus is a ubiquitous, host-adapted pathogen that causes various disease states. There are two types of HSV with two distinct DNA viruses, type 1 (HSV-1) and type 2 (HSV-2). Both the types are closely related but differ epidemiologically. HSV-1 is traditionally associated with orofacial disease by affecting the mouth and lips with fever blisters and cold sores, whereas HSV-2 is associated traditionally with genital disease infecting genitals and rectum area with sores and is classified as STD (sexually transmitted disease). As HSV-1 is associated with genital infections more often than HSV-2, lesion location is not necessarily of viral type. HSV can spread through direct contact. Almost 80% of Herpes simplex infections are asymptomatic, while symptomatic infections can be characterized by significant morbidity and recurrenc...
Read more

HR+/HER2- Breast Cancer – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Image
Thelansis’s “HR+/HER2- Breast Cancer Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential HR+/HER2- Breast Cancer treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China). KOLs insights of HR+/HER2- Breast Cancer across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs. HR+/HER2- Breast Cancer Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model,...
Read more