Hepatitis B – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 

Hepatitis B is primarily transmitted via contact with infected blood or certain bodily fluids. Common transmission routes include perinatal transfer from an infected mother to her newborn during childbirth, unsterile medical or dental equipment, unprotected sex, unsterile needles, and sharing personal items such as razors, toothbrushes, and nail clippers. Hepatitis B is often termed a “silent epidemic” as most individuals are asymptomatic during acute or chronic infection, leading to unintentional viral transmission and ongoing propagation of the virus. Chronic asymptomatic carriers may still experience progressive liver damage, potentially resulting in cirrhosis or liver cancer. The hepatitis B virus (HBV) has a complex replication cycle, entering host liver cells and transforming its DNA into covalently closed circular DNA (cccDNA) within the nucleus. This cccDNA serves as a template for viral replication. Newly formed HBV particles are released from the liver cell while cccDNA persists in the nucleus, where it can integrate into the host genome and continue viral production. The replication process is prone to errors, contributing to the genetic diversity of HBV. The differential diagnosis for hepatitis B includes other hepatitis viruses (A, C, E), alcoholic hepatitis, and autoimmune hepatitis, necessitating thorough clinical evaluation and laboratory testing. Conditions like hemochromatosis, characterized by abdominal tenderness and abnormal liver transaminase levels, should also be considered. Hemochromatosis may present distinctive features like bronze skin discoloration and impaired glucose tolerance. Acute hepatitis B resolves spontaneously in 95% of healthy adults, with most cases requiring only supportive care. Severe acute cases (bilirubin >10 mg/dl, INR >1.6, hepatic encephalopathy) and prolonged severe cases (total bilirubin >3 mg/dl, direct bilirubin >1.5 mg/dl, INR >1.5, hepatic encephalopathy, ascites) warrant antiviral therapy. FDA-approved treatments for chronic hepatitis B include interferons (peginterferon alfa-2a, interferon alfa-2b), nucleoside analogs (entecavir, lamivudine, telbivudine), and nucleotide analogs (adefovir, tenofovir), with entecavir and tenofovir preferred for their higher resistance barrier in acute infections.

 

Thelansis’s “Hepatitis B Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Hepatitis B treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Hepatitis B across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Hepatitis B Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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