Adrenocortical carcinoma (ACC) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2022 To 2032

Adrenocortical carcinoma (ACC) is rare cancer that affects the adrenal gland and primarily affects individuals in early adulthood and between the ages of 40-50. Women are more commonly affected, comprising 55-60% of cases. The majority of ACC cases are of sporadic origin. However, they can also develop as part of familial diseases such as Beckwith-Wiedeman syndrome, Li-Fraumeni syndrome, Lynch syndrome, multiple endocrine neoplasia (MEN), and familial adenomatous polyposis (FAP). There are three main clinical presentations of ACC: hormone excess symptoms and signs in 40-60% of patients, non-specific symptoms due to local tumor growth such as abdominal or flank pain, abdominal fullness, or early satiety in a third of patients. Although the specific genetic alterations involved in ACC development are currently unknown, chromosomal abnormalities have been identified in hereditary neoplasia syndromes. The Wnt/β-catenin constitutive activation and insulin growth factor 2 (IGF2) overexpression are the most important implicated genetic pathways. The protein steroidogenic factor 1 (SF1) plays a significant role in adrenal development and is often overexpressed in ACC. Treatment of ACC requires a multidisciplinary approach, with initial surgical resection in limited disease (stages I, II, and occasionally III). Mitotane (1,1-dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane [o,p’DDD]) is the only currently available adrenolytic medication, achieving an overall response rate of approximately 30%. The five-year survival rate for ACC varies depending on the presentation stage, with the ENSAT system reporting rates of 82% for stage I, 61% for stage II, 50% for stage III, and 13% for stage IV.

·       In the USA, adrenocortical carcinoma annual incidence is estimated to be 1.02 per one million population.

Thelansis’s “Adrenocortical carcinoma (ACC) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Adrenocortical carcinoma (ACC) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Adrenocortical carcinoma (ACC) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Adrenocortical carcinoma (ACC) Market Forecast Patient-Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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