Autosomal Dominant Osteopetrosis Type 2 – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032


 Autosomal dominant osteopetrosis type 2 is characterized by segmentary osteosclerosis, predominantly at the vertebral endplates, iliac wings, and skull base. Clinical manifestations include cranial nerve palsies, osteoarthritis of the hip, mandibular osteomyelitis, and nontraumatic fractures, particularly of the long bones. OPTA2 is responsible for 70% of autosomal dominant osteopetrosis cases. Symptoms and severity can vary greatly, ranging from the neonatal onset with life-threatening complications to the incidental finding of osteopetrosis on X-ray. Depending on the severity and age of onset, features may include fractures, short stature, compressive neuropathies, hypocalcemia with attendant tetanic seizures, and life-threatening pancytopenia. There may be neurological impairment or involvement of other body systems in rare cases. Osteopetrosis is classified based on clinical features, mode of inheritance and molecular mechanism. There are various clinical features and genes involved in different types of osteopetrosis. Inheritance type can be autosomal recessive, autosomal dominant or X-linked. Autosomal recessive osteopetrosis (ARO), a malignant form of osteopetrosis that can be seen in infancy, can result in growth failure and increased frequency of fractures.

·       Autosomal dominant osteopetrosis type 2 (ADO2) prevalence ranges from 0.2 to 5.5 in 100,000 cases. However, asymptomatic carriers were reported with some mutations, and non-penetrance rates were 24 to 41%, depending on mutations, in families with ADO2, and most of them are asymptomatic at younger ages.

Thelansis’s “Autosomal Dominant Osteopetrosis Type 2 Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Autosomal Dominant Osteopetrosis Type 2 treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

KOLs insights of Autosomal Dominant Osteopetrosis Type 2 across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Autosomal Dominant Osteopetrosis Type 2 Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

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