Congenital Heart Block – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032


 Congenital heart block or atrioventricular block is a loss in the normal function of the cardiac electroconductive pathways that connect the sinoatrial node (SA node) to the ventricles via conduction through the atrioventricular node (AV node). The congenital heart block associated with neonatal lupus is a form of passively acquired autoimmune disease in which maternal autoantibodies to the intracellular ribonucleoproteins Ro (SS-A) and La (SS-B) cross the placenta and injure the previously normal fetal heart. Women with serum titers of anti-Ro antibody carry a 3% risk of having a child with neonatal lupus syndrome. Recurrence rates are about 18%. Chronic idiopathic fibrosis and sclerosis of the conduction system in Lenegre's disease cause half of the cases. Another common cause is ischemic heart disease, responsible for 40% of cases. It is associated with hypertrophic obstructive cardiomyopathy and infiltrative diseases like sarcoidosis and amyloidosis. First-degree congenital blocks can originate from various locations within the conduction system. The level of conduction delay includes the atrium, AV node (most common in first-degree block), Bundle of His, fascicles, Bundle Branches, and Purkinje system. Mobitz type I second-degree congenital block originates from conduction system disease below the level of the atrioventricular node. In third-degree atrioventricular block, no impulses will reach the ventricle and occur in the atrioventricular node or the intranodal specialized conduction system.

The incidence of congenital heart block ranges from 1 to 2 cases per 50,000 live births, associated with high mortality and morbidity in the USA.

 

The competitive landscape of Congenital Heart Block includes country-specific approved and pipeline therapies. Any asset/product-specific designation, review, and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Congenital Heart Block across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Congenital Heart Block Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, Product Event, Country specific Forecast Model, Market uptake, and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

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