Cocaine Intoxication – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032


 Cocaine intoxication and abuse are characterized by adrenergic hyperactivity and increased blood pressure. Cocaine use is linked to acute hypertension but not chronic hypertension. Severe hypertension has been reported in propranolol-treated subjects due to unopposed peripheral -stimulation. A 40-year-old woman was treated successfully with nitroprusside and captopril for hypertensive encephalopathy caused by cocaine abuse. Cocaine use during pregnancy increases the risk of premature placental abruption and blood pressure elevation, less responsive to standard therapy than pregnancy-induced hypertension. Cocaine use has been linked to sudden death due to various causes, including cardiac arrhythmias, respiratory arrest, status epilepticus, and impaired thermoregulation. Cocaine use during pregnancy increases the risk of placental abruption and emergency cesarean delivery. This medication binds and blocks monoamine reuptake transporters (dopamine, norepinephrine, and serotonin) with equal affinity. Monoamines accumulate in the synaptic cleft, causing sympathetic effects to be enhanced and prolonged. Cocaine's direct effects on the cardiovascular system are due to alpha- and beta-1-adrenoceptor stimulation, which causes an increase in heart rate, systemic arterial pressure, and myocardial contractility, all of which are essential determinants of myocardial oxygen demand. Cocaine and its metabolites can cause arterial vasoconstriction for several hours after use.

 

The incidence of Cocaine intoxication cases ranges from 3.5 to 7.8 cases per 100,000 population in the USA.

 

The competitive landscape of Cocaine Intoxication includes country-specific approved and pipeline therapies. Any asset/product-specific designation, review, and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Cocaine Intoxication across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Cocaine Intoxication Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Cocaine Intoxication – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2021 To 2032

S. No    Asset               Company                                 Stage

1          TNX-1300         Tonix Pharmaceuticals, Inc.       Phase 2

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