Fuchs Endothelial Dystrophy (FED) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032


 Fuchs endothelial dystrophy (FED) is a primary, progressive corneal endothelial disorder that causes corneal edema and vision loss. The first signs of FED usually appear between the fifth and seventh decades of life. They are characterized by progressive accumulation of focal excrescences, termed “guttae,” and thickening of Descemet’s membrane, a collagen-rich layer secreted by endothelial cells. Endothelial cell density and functionality as the cornea's "pump" eventually decline, resulting in vision-threatening corneal edema. Although the presence of corneal guttae is not pathognomonic for FED, the development of stromal edema does. Symptoms include visual blurring, most notably in the morning, and stromal and epithelial edema caused by relatively low tear film osmolality. FED has been linked to mutations in collagen VIII, a vital component of the Descemet's membrane secreted by endothelial cells. FED is divided into four stages, beginning with early signs of guttae formation and progressing to end-stage subepithelial scarring. The biomicroscopic examination is used to diagnose; other modalities, such as corneal pachymetry, confocal microscopy, and specular microscopy, can be used in conjunction.

The prevalence of Fuchs endothelial dystrophy (FED) ranges from 2.9% to 5.2% of the >=40 population in the USA.

 

The competitive landscape of Fuchs Endothelial Dystrophy (FED) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Fuchs Endothelial Dystrophy (FED) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Fuchs Endothelial Dystrophy (FED) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Fuchs Endothelial Dystrophy (FED) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2021 To 2032

S. no    Asset   Company         Stage

1          Netarsudil Ophthalmic Solution   Price Vision Group        Phase 3

2          TTHX1114 (NM141)      Trefoil Therapeutics, Inc.           Phase 2

3          Netarsudil Ophthalmic Solution   Aerie Pharmaceuticals   Phase 2

4          QR-504a           ProQR Therapeutics      Phase 1

5          EO2002            Emmecell          Phase 1

6          Elamipretide      Stealth BioTherapeutics Inc.      Phase 2

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