Cardiogenic Shock – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2021 To 2032


 Cardiogenic shock (CS) is a complex and highly morbid entity conceptualized as a vicious cycle of injury, cardiac and systemic decompensation, and further damage and decompensation. The primary insult is a reduction in myocardial contractility resulting in diminished cardiac output, hypotension, systemic vasoconstriction, and cardiac ischemia. The hallmark is peripheral vasoconstriction and vital end-organ damage, resulting from ineffective stroke volume and insufficient circulatory compensation. Compensatory peripheral vasoconstriction may initially improve coronary and peripheral perfusion. However, it contributes to increased cardiac afterload that overburdens damaged myocardium. This results in diminished oxygenated blood flow to peripheral tissue and the heart. Systemic inflammation causes pathological vasodilation, releasing nitric oxide synthase and peroxynitrite, which have cardiotoxic inotropic effects. Interleukins and tumor necrosis factor-alpha (TNF-a) are additional systemic inflammatory mediators that result in vasodilation and contribute to mortality in patients with CS. In the setting of CS, classic ACS symptoms and signs are combined with altered mental status, hypotension, arrhythmia, diminished pulses, dyspnea, peripheral edema, jugular venous distention, and orthopnea.

The incidence of Cardiogenic Shock ranges from 8% to 11% cases of all Acute myocardial infarction (AMI) cases.

 

The competitive landscape of Cardiogenic Shock includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Cardiogenic Shock across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Cardiogenic Shock Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Cardiogenic Shock – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2021 To 2032

S. No    Asset               Company                                 Stage

1          Istaroxime         Windtree Therapeutics   Phase 2

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