Acute Graft-Versus-Host Disease (GVHD) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030


 After an allogeneic hematopoietic stem cell transplant, acute graft-versus-host disease (GVHD) is a reaction of donor immune cells against host tissues. After an inflammatory cascade that starts with the preparative regimen, activated donor T cells, damage host epithelial cells. Acute GVHD affects approximately 35–50% of hematopoietic stem cell transplant (HSCT) recipients. The specific risk is determined by the stem cell source, patient age, conditioning, and GVHD prophylaxis. The number and extent of organ involvement in acute GVHD are staged and graded (grade 0-IV). Patients with acute GVHD of grade III/IV have a poor prognosis. The patient is generally treated by improving their immunosuppression and supplementing with methylprednisolone. Methylprednisolone will be effective in about half of the patients. If patients do not improve after three days or if they do not improve after seven days, they will receive salvage (second-line) immunosuppressive therapy, for which there is currently no standard of care.

 

Acute Graft-Versus-Host Disease (GVHD) incidence ranges from 16 to 20 cases per million in the USA.

 

The competitive landscape of Acute Graft-Versus-Host Disease (GVHD) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Acute Graft-Versus-Host Disease (GVHD) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Acute Graft-Versus-Host Disease (GVHD) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Acute Graft-Versus-Host Disease (GVHD) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          ASC930            ASC Therapeutics         Phase 2

2          Jaktinib Hydrochloride Tablets    Suzhou Zelgen Biopharmaceuticals            Phase 2

3          T-Guard            Xenikos Phase 3

4          Remestemcel-L Mesoblast, Inc.  Phase 3

5          MC0518            medac GmbH   Phase 3

6          Itolizumab         Equillium           Phase 3

7          Defibrotide        Jazz Pharmaceuticals    Phase 2

8          natalizumab      Biogen  Phase 2

9          Alpha-1 antitrypsin (AAT)           CSL Behring     Phase 3

10        MaaT013          MaaT Pharma   Phase 3

Continued

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