Metastatic clear cell renal cell carcinoma (RCC) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030


 Renal cell carcinoma (RCC), the eighth most common malignancy affecting adults, accounts for between 3% and 4% of new cancer cases in the United States. The classic clinical presentation of flank pain, hematuria, and a palpable flank mass are comparatively uncommon (5–10% of cases). However, clinical symptomatology may be relatively nonspecific. For example, anorexia, tiredness, weight loss, or fever of unknown origin · The clear cell histologic subtype remains the most common representing approximately 70% of all renal tumors and an even more significant proportion of patients with metastatic RCC (>80%). The vast majority of clear cell RCC is characterized by biallelic loss of function of the von Hippel Lindau (VHL) tumor suppressor gene. Prognosis is generally reflected in staging severity, with the lower-stage disease associated with longer survival rates. The prediction is noticeably adversely affected by the spread of the tumor beyond the renal fascia and into the retroperitoneum (TNM T3a and higher) · The more common sites of metastases as reported in stage IV disease (TNM T4 or N1+ M1 disease) are the lung (69%), bone (43%), liver (34%), lymph nodes (22%), adrenal gland (19%), brain (7%), and thyroid, skin, and bladder (< 1% each)

The prevalence of patients present with localized disease. However, approximately one-third present with locally advanced or metastatic disease, and up to 30% of patients undergoing surgical resection will experience recurrent disease.

The competitive landscape of Metastatic clear cell renal cell carcinoma (RCC) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Metastatic clear cell renal cell carcinoma (RCC) across the 8 MM market from the center of Excellence/ Public/ Private hospitals participated. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Metastatic clear cell renal cell carcinoma (RCC) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Metastatic clear cell renal cell carcinoma (RCC) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          ALLO-316         Allogene Therapeutics   Phase 1

2          Batiraxcept       Aravive, Inc.      Phase 2

3          AK104  Akeso   Phase 2

4          Sitravatinib        Mirati Therapeutics Inc. Phase 1

5          Cabozantinib     Ipsen    Phase 2

6          lenvatinib          Eisai Inc.          Phase 2

7          Lipotecan          Taiwan Liposome Company       Phase 2

8          CB-839 Calithera Biosciences, Inc          Phase 2

9          VB10.NEO        Nykode Therapeutics AS           Phase 2

10        Atezolizumab    Exelixis Phase 3

Continued

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