Gastrointestinal Stromal Tumors (GISTs) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030


 Gastrointestinal Stromal Tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Approximately 80% of GISTs harbor activating mutations in the KIT or PDGFRA genes responsible for the up-regulation of crucial signaling pathways, including MAPK and PI3K-AKT. GISTs lacking KIT and PDGFRA mutations are referred to as “wild-type” (wt)-GIST. GISTs can develop in the colon, rectum, esophagus, mesentery, and omentum and are most commonly found in the stomach (60 percent) and small intestine (25 percent). They can also evolve in the colon, rectum, esophagus, mesentery, and omentum (15 percent together). Fatigue, abdominal pain, dysphagia, satiety, and obstruction are all symptoms associated with GISTs. One or more GISTs develop in 7% of patients with neurofibromatosis type I (NF1). Most cancers start in the small intestine and do not spread quickly. Most of these GISTs are KIT and PDGFRA wild-type, but as expected, they have somatic mutations or loss of the remaining wild-type NF1 allele, resulting in MAP kinase signaling.

In the United States, gastrointestinal stromal tumors (GISTs) incidence varies between 11 and 17 cases per million adults per year.

The competitive landscape of Gastrointestinal Stromal Tumors (GISTs) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Gastrointestinal Stromal Tumors (GISTs) across the 8 MM market from the center of Excellence/ Public/ Private hospitals participated. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Gastrointestinal Stromal Tumors (GISTs) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Gastrointestinal Stromal Tumors (GISTs) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Ripretinib          Zai Lab Phase 2

2          TNO155            Novartis Pharmaceuticals          Phase 1

3          PLX9486           Plexxikon          Phase 2

4          Masitinib           AB Science       Phase 3

5          BAY73-4506 (Regorafenib, Stivarga)      Bayer   Phase 2

6          Ripretinib          Deciphera Pharmaceuticals LLC Phase 1

7          Intuvax (ilixadencel)       Immunicum AB  Phase 1

8          avapritinib         Blueprint Medicines Corporation Phase 3

9          Ganetespib       Synta Pharmaceuticals Corp      Phase 2

10        Perifosine         AEterna Zentaris           Phase 2

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