Canavan disease (CD) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030


 Canavan disease (CD) is a genetic degenerative brain disease caused by a lack of the enzyme aspartoacylase (ASPA). N-acetylaspartic acid builds up in the brain and other body parts when ASPA activity is lost. CD is diagnosed by detecting elevated NAA in urine, blood, or the brain by proton MR spectroscopy and ASPA mutation analysis. Insufficient myelination and progressive spongy degeneration of the brain's white matter characterize the disease histologically. While not all Canavan disease (CD) patients had epilepsy in their early years, seizure prevalence increased over the first decade, with all CD patients having seizures by ten. Multiple antispasmodic or antiepileptic drugs are frequently required to treat neurological symptoms such as seizures and spasticity. Canavan disease (CD) is caused by mutations in the ASPA gene (17p13.3), which codes for the aspartoacylase enzyme. Numerous mutations have been discovered, and enzymatic activity is either low or non-existent as a result.

The incidence of Canavan disease (CD) varies between 1 to 1.5 cases per 100,000 birth population in the USA.

The competitive landscape of Canavan disease (CD) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Canavan disease (CD) across the 8 MM market from the center of Excellence/ Public/ Private hospitals participated. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Canavan disease (CD) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Canavan disease (CD) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          rAAV-Olig001-ASPA      Myrtelle Inc.      Phase 2

2          AAV9 BBP-812 Aspa Therapeutics        Phase 2

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