Adrenomyeloneuropathy (AMN) – Market outlook, Epidemiology, Competitive Landscape and Market Forecast Report – 2020 To 2030


 Adrenomyeloneuropathy (AMN) is an inherited condition that affects the spinal cord. It is a form of X-linked adrenoleukodystrophy (X-ALD), characterized by spastic paraparesis and often associated with peripheral adrenal insufficiency in males.

Etiology-

AMN is due to mutations of ABCD1 (Xq28) encoding ALDP, a peroxisomal transmembrane protein involved in the transport of very long-chain fatty acid-CoA esters (VLCFA) into the peroxisome. Oxidative stress and damage to proteins and lipids due to VLCFA accumulation in glial cells (oligodendrocytes, Schwann cells) may impair their capacity to sustain axonal integrity in the spinal cord and peripheral nerves.

Epidemiology-

X-ALD estimated birth incidence is 1/20,000. Adrenomyeloneuropathy (AMN) manifests in more than 60% of female patients in adulthood and nearly all male patients who reach adulthood.

The competitive landscape of Adrenomyeloneuropathy (AMN) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Adrenomyeloneuropathy (AMN) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Adrenomyeloneuropathy (AMN) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Adrenomyeloneuropathy (AMN) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          MD1003            MedDay Pharmaceuticals SA     Phase 2/3

2          Lenti-D bluebird bio       Phase 2/3

3          VK0214 Viking Therapeutics, Inc.           Phase 1

4          MIN-102           Minoryx Therapeutics, S.L.        Phase 2/3

5          Cholic Acids      Travere Therapeutics, Inc.         Phase 3

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