Acute Hepatic Porphyria – Market outlook, Epidemiology, Competitive Landscape and Market Forecast Report – 2020 To 2030


 A rare sub-group of porphyrias is characterized by the occurrence of neuro-visceral attacks with or without cutaneous manifestations. Acute hepatic porphyrias encompass four diseases: acute intermittent porphyria (the most common), variegate porphyria, hereditary coproporphyria, and hereditary deficit of delta-aminolevulinic acid dehydratase (extremely rare).

Etiology-

Each acute hepatic porphyria is a result of a deficiency of one of the enzymes in the heme biosynthesis pathway. These deficiencies result in an accumulation of the precursors of porphyrins in the liver (delta-aminolevulinic acid, ALA, and porphobilinogen, PBG) and also, in the case of variegate porphyria and hereditary coproporphyria, an accumulation of porphyrins resulting in cutaneous manifestations.

Epidemiology-

In the United States, the prevalence of porphyria is approximated to be one in 25,000 individuals.[6] The worldwide prevalence is approximated to range from one in 500 to one in 50,000 individuals.

In the majority of European countries, the prevalence of acute hepatic porphyrias is around 1/75,000. In 80% of cases, the patients are female, with the majority aged between 20 to 45 years.

The competitive landscape of Acute Hepatic Porphyria includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are being tracked and supplemented with analyst commentary.

KOLs insights of Acute Hepatic Porphyria across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Acute Hepatic Porphyria  Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Acute Hepatic Porphyria  – Market outlook, Epidemiology, Market Forecast and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Givosiran          Alnylam Pharmaceuticals           Phase 3

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