Multiple system atrophy (MSA) – Market outlook, Epidemiology, Competitive Landscape and Market Forecast Report – 2020 To 2030


 Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment, and corticospinal signs with a median survival of 6-9 years.

 

Etiology-

The etiology of MSA is unknown but the presence of cytoplasmic aggregates of α-synuclein, primarily in oligodendroglia, in combination with neurodegeneration in striatonigral and olivopontocerebellar structures are the pathological hallmark features. Mutations in COQ2 (4q21.23) (encoding an enzyme involved in the biosynthesis of coenzyme Q10) have been shown in multiplex families with MSA, while some variants were associated with an increased risk for sporadic MSA.

 

Epidemiology-

The incidence of MSA in the United States is estimated at 0.6 cases per 100,000 people per year in the general population giving a current estimate of about 1,900 new cases per year in the USA. A prevalence study in London, UK, gave an age-adjusted figure of 4.4 living cases per 100,000 population at any one time, which would currently translate to about 14,000 living cases in the USA.

 

The competitive landscape of Multiple system atrophy (MSA) includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are being tracked and supplemented with analyst commentary.

KOLs insights of Multiple system atrophy (MSA) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Multiple system atrophy (MSA) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Multiple system atrophy (MSA) – Market outlook, Epidemiology, Market Forecast and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Verdiperstat      Biohaven Pharmaceuticals, Inc. Phase 3

2          AAV2-GDNF gene therapy         Brain Neurotherapy Bio, Inc.            Phase 1

3          BIIB101 Biogen  Phase 1

4          CS10BR05        Corestem, Inc.  Phase 1

5          Safinamide Methanesulfonate    Zambon SpA     Phase 2

6          AZD3241          AstraZeneca     Phase 2

7          NBMI    EmeraMed        Phase 2

8          AFFITOPE® PD01A + Adjuvant Affiris AG          Phase 1

9          DaTSCAN™ Ioflupane (123I) Injection    GE Healthcare  Phase 3

10        Droxidopa         H. Lundbeck A/S           Phase 2

Continued.

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