Atypical Hemolytic Uremic Syndrome (aHUS) – Market outlook, Epidemiology, Competitive Landscape and Market Forecast Report – 2020 To 2030

Atypical hemolytic uremic syndrome (aHUS) is an extremely rare disease characterized by low levels of circulating red blood cells due to their destruction (hemolytic anemia), low platelet count (thrombocytopenia) due to their consumption and inability of the kidneys to process waste products from the blood and excrete them into the urine (acute kidney failure), a condition known as uremia.

Etiology-

The genes associated with genetic aHUS include C3, 

CD46 (MCP), CFB, CFH, CFHR1, CFHR3, CFHR4, CFI, DGKE, and THBD. Mutations in these genes increase the likelihood (predisposition) to developing aHUS, rather than directly causing the disease. Most cases are sporadic. In familiar cases, predisposition to aHUS is inherited in an autosomal dominant or an autosomal recessive pattern of inheritance.

Epidemiology-

The exact overall incidence and prevalence is unknown. One study placed the incidence in the United States at 2 individuals per 1 million in the general population. In Europe, the disorder is estimated to affect approximately .11 per 1 million individuals between the ages of 0-18.

The competitive landscape of Atypical Hemolytic Uremic Syndrome (aHUS) includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are being tracked and supplemented with analyst commentary.

KOLs insights of Atypical Hemolytic Uremic Syndrome (aHUS) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Atypical Hemolytic Uremic Syndrome (aHUS) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Atypical Hemolytic Uremic Syndrome (aHUS) – Market outlook, Epidemiology, Market Forecast and Competitive Landscape Report – 2020 To 2030

S. No    Asset                           Company                                 Stage

1          Crovalimab       Chugai Pharmaceutical  Phase 3

2          Ravulizumab     Alexion Pharmaceuticals            Phase 3

3          Iptacopan         Novartis Pharmaceuticals          Phase 3

4          OMS721           Omeros Corporation      Phase 3

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