Thelansis

  Essential tremor (ET) is among the most prevalent and common neurodegenerative movement disorders. It is an enhanced physiological monosymptomatic condition transmitted as an autosomal dominant trait. Essential tremor (ET) could be childhood- and adult-onset cases, which are similar and usually appear in the second decade but can begin as early as 2 years of age. Typically, the tremor is marked in the upper limbs and involves the head, voice, lower limbs, and trunk. Despite its high prevalence, ET is still frequently undiagnosed or misdiagnosed, and public recognition of the disease and its impact remain low. Furthermore, many patients with ET, particularly those with initial episodes of tremors, do not seek medical care, remain undiagnosed, and do not receive treatment. Essential tremors most often affect the hands and arms bilaterally and are symmetric; also, cases of asymmetric essential tremors have been reported. In most cases, the tremor frequency of e...

  Microsatellite stability status in colorectal cancer is both a prognostic and a predictive biomarker that has significant importance in diagnosis and treatment. Microsatellite stability testing confirms whether the DNA segments have several or a few mutations. This helps determine the therapy and clinical practice, such as conventional chemotherapy drugs or immune checkpoint blockade with immunotherapy drugs, which may be more or less effective against a particular colorectal cancer. Colorectal cancer, commonly known as colon cancer, primarily arises in the colon or rectum; it is the third most prevalent form of cancer known for its slow progression over many years. Typically, it originates as a non-malignant polyp, an unusual tissue growth lining the colon. There are three main presentations of colorectal cancer: sporadic (70%), familial clustering (20%), and inherited syndrome (10%). Various risk factors are linked to the development of colon cancer, including age, environmen...

  Microsatellite stability status in colorectal cancer is both a prognostic and a predictive biomarker that has significant importance in diagnosis and treatment. Microsatellite stability testing confirms whether the DNA segments have several or a few mutations. This helps determine the therapy and clinical practice, such as conventional chemotherapy drugs or immune checkpoint blockade with immunotherapy drugs, which may be more or less effective against a particular colorectal cancer. Colorectal cancer, commonly known as colon cancer, primarily arises in the colon or rectum; it is the third most prevalent form of cancer known for its slow progression over many years. Typically, it originates as a non-malignant polyp, an unusual tissue growth lining the colon. There are three main presentations of colorectal cancer: sporadic (70%), familial clustering (20%), and inherited syndrome (10%). Various risk factors are linked to the development of colon cancer, including age, environmen...