Hemophagocytic Lymphohistiocytosis (HLH) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome (HPS), is a rare, life-threatening hematologic disorder manifested by clinical findings of extreme inflammation and unregulated immune activation. In both its congenital (primary) and adult (secondary) forms, an underdiagnosed syndrome is caused by the overwhelming dysregulation of the immune system, resulting in end organ damage or even death if untreated. It is described as a hyperinflammatory reaction with uncontrolled, persistent activation of lymphocytes and macrophages engulfing hematopoietic cells, creating a vicious cycle of a cytokine storm. The diagnostic criteria of HLH involve a molecular diagnosis or meeting five of the eight criteria, including fever, splenomegaly, bicytopenia, hypertriglyceridemia and hypofibrinogenemia, hemophagocytosis in the bone marrow, low or absent NK cell activity, elevated ferritin levels and elevated soluble CD25 levels. Hyperferritinemia and elevated soluble CD25 are excellent predictors of cytokinemia as elevated ferritin levels reflect activated macrophages and soluble CD25 is the gold standard of T-cell activation.

·       In the USA, about 25% of pediatric cases are primary Hemophagocytic lymphohistiocytosis (PHLH), whereas nearly all adult cases are secondary HLH; the annual incidence rate of PHLH is 1 to 2 cases per million children population.

 

Thelansis’s “Hemophagocytic Lymphohistiocytosis (HLH) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Hemophagocytic Lymphohistiocytosis (HLH) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Hemophagocytic Lymphohistiocytosis (HLH) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Hemophagocytic Lymphohistiocytosis (HLH) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Hemophagocytic Lymphohistiocytosis (HLH) – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Hemophagocytic Lymphohistiocytosis (HLH), Hemophagocytic Lymphohistiocytosis (HLH) market outlook, Hemophagocytic Lymphohistiocytosis (HLH) competitive landscape, Hemophagocytic Lymphohistiocytosis (HLH) market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

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