Alport Syndrome – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033


 Alport syndrome, a genetic condition, presents with kidney disease, hearing loss, and eye abnormalities. It arises from mutations in three genes: COL4A3, COL4A4, or COL4A5, each responsible for a component of type IV collagen crucial in kidney glomeruli. In 80% of cases, it follows an X-linked pattern due to COL4A5 mutations, though other inheritance patterns exist. X-linked Alport syndrome manifests as:

1.       Juvenile form: Renal insufficiency appears between ages 20 and 30

2.       Adult form: Renal insufficiency occurs after 30

About 50% of males in the X-linked form require dialysis or kidney transplantation by 30, and 90% develop ESRD before 40. Females have a 12% ESRD risk by age 40, increasing to 30% by age 60. Proteinuria and hearing loss in females elevate ESRD risk. Differential diagnoses include Immunoglobulin A nephropathy, Thin GBM disease, Acute post-streptococcal glomerulonephritis, Medullary cystic disease, Multicystic renal dysplasia, and Polycystic kidney disease. Alport syndrome lacks specific treatment; the focus is on limiting proteinuria and kidney disease progression. Options include angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) for managing proteinuria, hypertension, and CKD.

·       Alport syndrome affects an estimated 1 in 5,000-10,000 in the U.S., totaling 30,000-60,000 people. It accounts for 3% of childhood chronic kidney disease and 0.2% of adult end-stage renal disease cases in the country.

 

Thelansis’s “Alport Syndrome Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Alport Syndrome treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China).

 

KOLs insights of Alport Syndrome across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Alport Syndrome Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources.

Read more: Alport Syndrome – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Tags: Alport Syndrome, Alport Syndrome market outlook, Alport Syndrome competitive landscape, Alport Syndrome market forecast, Thelansis, Primary market research, KOL insights, Competitive Intelligence (CI)

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