Hypothalamic Obesity (HO) – Market outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2020 To 2030


 Hypothalamic obesity (HO) is a severe and heterogeneous disease related to several conditions, such as hypothalamic damage caused by tumors and their treatment, inflammatory, trauma, neurosurgery, cerebral aneurysm, single-gene mutations (e.g., leptin, leptin receptor, CART, POMC), rare congenital disorders with midline, genetic syndromes, and the use of psychotropic drugs. The weight gain pattern in HO patients is characterized by a sudden onset and rapid acceleration after hypothalamic damage. The symptoms of hypothalamic obesity vary by the cause and include uncontrollable hunger, rapid, excessive weight gain, and a low metabolic rate. If the pituitary gland is involved, symptoms may consist of small underdeveloped testes in males and delayed puberty. This condition most often occurs because of injury to the hypothalamus due to a tumor, swelling in the brain, brain surgery, or head trauma.

 

The most common causes of acquired hypothalamic damage are space-occupying lesions, such as craniopharyngiomas and pituitary macroadenomas, with suprasellar extension and invasion of the hypothalamic nuclei.

As the most common cause of this condition, Craniopharyngiomas range between 1.5 to 2.8 cases per million population.

 

The competitive landscape of Hypothalamic Obesity (HO) includes country-specific approved and pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are tracked and supplemented with analyst commentary.

KOLs insights of Hypothalamic Obesity (HO) across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs.

Hypothalamic Obesity (HO) Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated Dashboard) which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights.

Read more: Hypothalamic Obesity (HO) – Market outlook, Epidemiology, Market Forecast, and Competitive Landscape Report – 2020 To 2030

S. No    Asset               Company                                 Stage

1          Setmelanotide   Rhythm Pharmaceuticals, Inc.    Phase 2

2          Exenatide         Amylin Pharmaceuticals, LLC.    Phase 1/2

3          Tesofensine      Saniona            Phase 2

4          ZGN-440          Zafgen, Inc.      Phase 2

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