Thelansis

  Autoimmune pulmonary alveolar proteinosis (aPAP) is a syndrome characterised by the accumulation of lipids and proteins related to surfactants in the alveoli in association with antibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). The disease causes progressive impairment of gas exchange and respiratory insufficiency. This blocks air from entering alveoli and oxygen from passing through into the blood, resulting in breathlessness. Most patients develop dyspnea very slowly over time, typically noticing it only with activity at first and eventually at rest. As the disease gets worse from the build-up of surfactant, the fingertips can become bluish in colour due to a low level of oxygen in the blood. Cough is the following most common symptom. This can be a dry or productive cough that produces whitish phlegm. Coughing phlegm with streaks of blood, with or without fever, usually indicates that infection is also present. The prevalence of Autoimmune pulmo...

  Acute Low back pain is pain, muscle tension, or stiffness, localised below the costal margin and above the inferior gluteal folds, with or without referred or radicular leg pain persists for <12 weeks. Acute LBP may be self-limiting, although there is a high recurrence rate with less-painful symptoms recurring in 50% to 80% of people within one year of the initial episode; 1 year later, as many as 33% of people still experience moderate-intensity pain and 15% experience severe pain. This type of pain is most common between the ages of 35 to 55 years. Symptoms, pathology, and radiological appearances are poorly correlated. An anatomical source of the pain cannot be identified in about 80% of people. Acute LBP is the 2nd most common symptomatic reason for office visits to primary care physicians and the most common sense for office visits to orthopaedic surgeons, neurosurgeons, and occupational medicine physicians. Recurrence of LBP is common; 60-80% of patients experience recur...

  Acute disseminated encephalomyelitis (ADEM) is a rare neurological disorder that affects children more than adults. However, it could affect any age group of the population but can affect anyone. It is characterised by a brief but widespread attack of fibreslammation in the brain and spinal cord that damages myelin, the protective covering of nerve fibres. Symptoms of ADEM rapidly begin with encephalitis symptoms such as fever, nausea, headache, fatigue and vomiting, and in the most serious cases, seizures and coma. ADEM typically causes white matter damage, resulting in neurological symptoms such as visual loss in one or both eyes, weakness, even paralysis, and difficulty coordinating voluntary muscle movements. ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS) because the symptoms and appearance of the white matter injury on brain imaging are similar. However, ADEM has several characteristics that set it apart from MS. The incidence of Acute...

  Tenosynovial giant cell tumour (TGCT) is a proliferative monoarticular lesion that occurs in and around joints throughout the body. TGCT is a group of lesions that develop from the synovium of joints, bursae, and tendon sheaths. There are two main subtypes of TGCT: localized-type TGCT (L-TGCT) and diffuse-type TGCT (D-TGCT). L-TGCT and D-TGCT behave differently and are categorized as separate clinical entities. Pain, swelling, stiffness, and limited range of motion are common symptoms. Other functional signs include instability, giving way and joint blockage. However, these nonspecific presentations can cause a delay in diagnosis and multiple visits to medical professionals. TGCT gene expression is consistent with apoptosis resistance, inflammation, and matrix degradation, resulting in ongoing proliferation and joint destruction. CD53, ALOX5AP, SPP1, and MMPs 1 and 9 are among the genes that are highly overexpressed. Complete excision of TGCT is the primary choice of treatment. D...

  Acromegaly is a disorder that occurs when your body makes too much growth hormone (GH). Produced mainly in the pituitary gland, GH controls the physical growth of the body. Acromegaly may also cause thickening of the body's soft tissues, including the heart, lips, and tongue. When the disease affects children prior to the end of puberty, excess growth hormone can lead to accelerated growth and tall stature, known as gigantism. Acromegaly affects between 3 and 14 people out of every 100,000. Thelansis’s “Acromegaly Market Outlook, Epidemiology, Competitive Landscape , and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Acromegaly treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and Chin...

  Frontotemporal dementia (FTD) describes a cluster of neurocognitive syndromes that present with impairment of executive functioning, behavioural changes, and a decrease in language proficiency. FTD is the second most common form of dementia in people under the age of 65, and its prevalence is expected to rise as the population ages. FTD is a highly heritable disorder despite varying heritability among different clinical syndromes and subtypes due to various gene mutations. Up to 50% of FTD cases with autosomal-dominant inheritance report a family history of FTD. Clinical diagnoses include behavioural variant FTD (bvFTD); primary progressive aphasia (PPA), which affects language; and disorders that primarily affect movement, progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). The annual prevalence of FTDs varies between 18 to 25 cases per 100,000 population in the USA. Thelansis’s “Frontotemporal Dementia (FTD) Market Outlook, Epidemiology, C...